Cancer is a metabolic disease. Dr Thomas Seyfried

[J.R.K]

Dr Thomas Seyfried is a Professor of biology at Boston College. In this interview Dr Seyfried gogoes into detail on the work done by Otto WWarburg, a researcher that is mentioned quite often within the Peat community.

There are many things in this video that will resonate with those following Dr Peats ideas and research, and some that will contrast with that work, specifically how the aspects of ketones, intermittent fasting, and The Keto diet can positively change the outcomes for cancer patients. He does admit that the research is only at the beginning stages but does describe the results he has witnessed.

I think that it is a step in the positive direction, regardless of the protocol and methodology. Just for a researcher to bring this from a mainstream medical school in my opinion speaks volumes, and I look forward to discussion on this topic.

[J.R.K]

This piece from Haidut has some research that supports partially the ideas that Dr Seyfried has on glutamine restriction. It may be that restricting arginine as well as glutamine might be a strategy to employ in order to induce autophagy in cancer patients.

Arginine / glutamine depletion may treat cancer by blocking the Warburg “Effect”

[Zack-Vegas]

I don’t know, doesn’t seem like much of a positive step forward to me.  He admits that cancer is a disruption of Oxidative Phosphorylation, and then starts to recommend protocols that will further impair Oxidative Phosphorylation.  His recommendations makes me think he didn’t learn about the basic biology of the processes he’s discussing.

How about, instead of a keto diet, trying to supplement with Krebs cycle intermediates that could help kick start Oxidative Phosphorylation, like succinate?  Or maybe offsetting lactate by supplementing pyruvate?  Or supplementing thyroid? Or, using extra fructose or sucrose to Oxidative Phosphorylation from a different pathway?

Trying to starve the body of glutamine and glucose seems like a recipe for cachexia, which is what a lot of cancer patients actually die from.  Just like a low calcium diet ignores the fact that we have a skeleton, a keto diet low in glucose and glutamine ignores the fact that we have muscle mass and vital organs, which contain a large amount of glutamine, and gluconeogenesis, the process that makes glucose out of almost all the amino acids.  Rather than the near impossible of task of trying to get rid of glutamine and glucose to stop fermentation, why not try to stop bacteria, which are crucial to the fermentation process?  I would think an antibiotic regimen would be much safer.

And again, this seems to be another cancer researcher completely blind to the role of iron.  What is in a lot of “processed carbohydrates?”  Ferrous sulfate, aka, iron, and iron devoid of the protective plant and animal protections that you would get from something like spinach or steak.  The Zacharky studies even demonstrated that lowering iron levels dramatically lowers the risk of both heart disease and cancer.

[J.R.K]

All of your points that you bring up are valid <span class=”atwho-inserted” contenteditable=”false” data-atwho-at-query=”@Za”>@Zack-Vegas </span>and I agree with the points on iron and substances that will both support and restore oxidative phosphorylation.

The Keto approach has been documented to induce the same responses as administering a glucocorticoid steroid as noted by Jay Feldman and Mike Fave.
Haidut also noted that intermittent fasting may not have any benefits and could be dangerous, in my opinion there seems to be no difference between this process and sarcopenia or as you point out cachexia which end stage cancer patients usually succumb to.

Intermittent fasting (IF) ineffective and may even be dangerous

The bodies own gluconeogenesis abilities seem to be overlooked in the synthesis of glucose and glutamine. But the advocates of this approach do seem to indicate that this approach induces a cleansing effect of sorts, depriving the body of food induces a selective consumption of foreign proteins and dysregulated cells. I question this claim. But at the same time need more information to better understand the claimed results.
Is it possible that there is another stress system at play that has not been fully observed, studied and understood yet?

[J.R.K]

To give a bioenergetic viewpoint on how keto and intermittent fasting affects the body, Jay, Danny, Mike, along with Kitty Blomfield. Go over some different testimonials.

[J.R.K]

Another short description as to how low carbohydrate diets drive cortisol.

[Author]

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