Cancer again – Is this the End, or just the beginning?

[J.R.K]

This might be helpful <span class=”atwho-inserted” contenteditable=”false” data-atwho-at-query=”@Kevin”>@Kevin007</span>

From Haiduts article:

Glycine (and leucine) can treat fatty liver disease (NASH NAFLD)

Whereas the above studies demonstrated glucose/lipid-lowering and hepatoprotective effects using higher glycine doses (≥1 mg/g per day) 19–22), we report here protective effects in the NASH model at a lower dose of 0.33 mg/g per day. Considering a 12.3-dose conversion factor between mice and humans (47), our findings suggest that a minimum of 27 mg/kg per day of glycine may have beneficial effects in humans.

I hope this is helpful.
Prayers go with you Kevin.

[Kevin007]

So House of Hope did blood work yesterday and I’m scheduled for a PET scan in an hour.
some interesting blood results!  Low Iron and high TSH among the oddities.

Glucose Level (Random), Blood (CHI)
Normal range: 74 – 106 mg/dL
98 mg/dL

Blood Urea Nitrogen Level, Blood (CHI)
Normal range: 6 – 20 mg/dL
16mg/dL

Creatinine Level, Blood (CHI)
Normal range: 0.70 – 1.20 mg/dL
0.72 mg/dL

Calcium Level, Blood (CHI)
Normal range: 8.6 – 10 mg/dL
9.3 mg/dL

Bilirubin Total, Blood (CHI)
Normal range: 0.0 – 1.2 mg/dL
0.3 mg/dL

Protein Total, Blood (CHI)
Normal range: 6.4 – 8.3 g/dL
7g/dL

Albumin Level, Blood (CHI)
Normal range: 3.5 – 5.2 g/dL
3.6g/dL

SGOT (AST) (CHI)
Normal range: 0 – 40 U/L
19 U/L

SGPT (ALT) (CHI)
Normal range: 0 – 41 U/L
12 U/L

Alkaline Phosphatase Level, Blood (CHI)
Normal range: 40 – 130 U/L
179 U/L

Sodium Level, Blood (CHI)
Normal range: 136 – 145 mmol/L
141 mmol/L

Potassium Level, Blood (CHI)
Normal range: 3.5 – 5.1 mmol/L
4.9 mmol/L

Chloride Level, Blood (CHI)
Normal range: 98 – 107 mmol/L
103.9 mmol/L

Carbon Dioxide Level, Blood (CHI)
Normal range: 22 – 29 mmol/L
27 mmol/L

eGFR, Blood CHI
Normal range: above >=60 mL/min/1.73 m²
Value >=60

Anion Gap, Blood (CHI)
Normal range: 5 – 15 mmol/L
10 mmol/L

Albumin / Globulin Ratio (CHI)
Normal range: 1.0 – 2.0
1.1

BUN / Creatinine Ratio (CHI)
Normal range: 10 – 20 RATIO
22 *high*

Calcium Level Corrected, Blood (CHI)
Normal range: 8.6 – 10 mg/dL
9.62 mg/dL

Activated Partial Thromboplastin Time (CHI)
Normal range: 22.5 – 34.7 Seconds
27.9 seconds

Activated Partial Thromboplastin Time (CHI)
Normal range: 22.5 – 34.7 Seconds
27.9 seconds

Iron, Blood (CHI)
Normal range: 59 – 158 ug/dL
61 ug/dL

Total Iron Binding Capacity (CHI)
Normal range: 250 – 450 ug/dL
275 ug/dL

Iron Saturation Percent (CHI)
Normal range: 20.0 – 55.0 %
22.25

Unsaturated IBC (CHI)
Normal range: 112 – 347 ug/dL
214 ug/dL

Iron, Blood (CHI)
Normal range: 59 – 158 ug/dL
61 ug/dL

Total Iron Binding Capacity (CHI)
Normal range: 250 – 450 ug/dL
275 ug/dL

Iron Saturation Percent (CHI)
Normal range: 20.0 – 55.0 %
22.2 %

Unsaturated IBC (CHI)
Normal range: 112 – 347 ug/dL
214 ug/dL

Protime (CHI)
Normal range: 11.5 – 13.9 Seconds
13.5 seconds

Inr (CHI)
Normal range: below 3.00 Ratio
1.04
INR THERAPEUTIC RANGE 2.0-3.0

Vitamin D, 25-Hydroxy (Screening for insufficiency) (CHI)
Normal range: 30 – 100 ng/mL
74.98 ng/mL

WBC Count (CHI)
Normal range: 4.00 – 10.50 K/uL
4.82 K/uL

RBC (CHI)
Normal range: 4.70 – 6.00 M/uL
4.59 M/uL

Hemoglobin (CHI)
Normal range: 13.5 – 18.0 g/dL
13.4 g/dL

Hematocrit (CHI)
Normal range: 42.0 – 52.0 %
42.6%

MCV (CHI)
Normal range: 78 – 100 fL
93 fL

MCH (CHI)
Normal range: 27.0 – 32.0 pg
29.2 pg

MCHC (CHI)
Normal range: 32.2 – 36.5 g/dL
31.5 g/dL

Platelets (CHI)
Normal range: 150 – 450 K/uL
218 K/uL

RDW (CHI)
Normal range: 11.5 – 14.0 %
13.7%

MPV (CHI)
Normal range: 9.0 – 12.0 fL
9.1 fL

Neutrophils Percent (CHI)
Normal range: 58 – 66 %
73 %

Lymphocyte Percent (CHI)
Normal range: 21 – 33 %
16%

Monocyte Percent (CHI)
Normal range: 4 – 8 %
9%

Eosinophil Percent
Normal range: 2 – 4 %
2 %

Basophil Percent (CHI)
Normal range: 0 – 1 %
1 %

NRBC Percent
%
Value
0.0

Neutrophil Absolute
Normal range: 1.5 – 6.6 K/uL
3.51 K/uL

Lymphocyte Absolute
Normal range: 1.8 – 3.3 K/uL
0.79 K/uL

Monocyte Absolute
Normal range: 0.10 – 1.00 K/uL
0.41 K/uL

Eosinophil Absolute
Normal range: 0.00 – 0.70 K/uL
0.07 K/uL

Basophil Absolute
Normal range: 0.00 – 0.10 K/uL
0.03 K/uL

Immature Grans (CHI)
Normal range: 0.0 – 0.0 %
Value 0.2 %

Absolute Immature Granulocytes (CHI)
Normal range: 0.00 – 0.10 K/uL
0.01 K/uL

Thyroid Stimulating Hormone, Serum (CHI)
Normal range: 0.270 – 4.200 uIU/mL
5.08 uIU/mL

Vitamin B12 Level, Blood (CHI)
Normal range: 232 – 1,245 pg/mL
Value
>4,000

Ferritin Level, Blood (CHI)
Normal range: 30 – 400 ng/mL
46.25 ng/mL

Free T4 (CHI)
Normal range: 0.92 – 1.68 ng/dL
.96 ng/dL

Folate, Serum (CHI)
Normal range: 7.3 – 26.1 ng/mL
8.9 ng/mL

I input all this into AI and asked it to “diagnose” based on the data alone and this is what it said:

Based on this constellation of findings, I suspect subclinical hypothyroidism with concurrent iron deficiency anemia and possible chronic low-grade inflammation or stress response.

I’ve been taking quite a bit of thiamine, niacinamide, biotin and aspirin.  I’m wondering if that would affect liver function and Thyroid? Especially if I didn’t get enough nutrition(glucose) to support the potential increase in metabolism?

High B12 could be from the eggs I eat😁

Thoughts?

[Zack-Vegas]

I’d disagree with the AI, there is nothing in the lab results to suggest anemia of any kind, and certainly not iron deficiency.

First, all the iron markers are in range.  They are on the low side, but based on what I read from the Weinberg book and other iron researchers, that is usually beneficial.  Ferritin is about what I personally target (I’ve actually tested much lower than that, and felt great).

Hemoglobin is a bit out of the listed range, but I remember when I first started donating blood over ten years ago, the low end cutoff was 12.0, for both men and women.  It was fairly recently that they upped the cutoff for males to 13.0.  This range is even higher than that. The Red Cross would allow you to donate blood with the hemoglobin level of 13.4, so even though that’s below the listed range, it still isn’t close to anemia territory.  That usually becomes a concern around 11.0, with 10.0 and under being fairly serious.

For an average American male, these iron numbers are a lot lower than you would expect.  It’s much closer to teenage iron levels.  If you have been doing a lot of blood tests, that could be a factor.  Blood testing usually takes 25-50 ml of blood per test tube.  When donating, 450 ml is taken.  So, if you have been doing a lot of blood tests, those small amounts can add up.  Also, a low iron diet can also lead to lower iron numbers.  Milk and eggs are especially good at lowering body iron stores, as they not only are low in iron, but also contain lactoferrin and (in milk) calcium, which also lower iron levels.  Aspirin can also lower iron levels.

So, for example, if you did a couple series of blood tests, eat little red meat, eat a lot of eggs and dairy, and take regular aspirin, all these things could have dramatically lowered iron levels.  But still, to levels that are in range and near deficiency, which should be good at slowing or possibly reversing cancer growth.

The high B12 levels are weird.  I would think that would either be from a supplement or lab error, don’t think that would have been just from eating eggs regularly.  Maybe regular eggs plus weekly liver?  I would also think this would have led to a higher hemoglobin level, although if you have been losing blood (through lots of blood testing or other procedures), that would make more sense.  In my personal experience, a B complex or iron free multi with the good forms of B12 and folate really helps to up hemoglobin levels.  As does Vitamin A.  And supplemental testosterone can REALLY increase levels.

[Kevin007]

Thank you J.R.K!  I always need reminding to get more glycine in my diet.  I might start a raw milk only diet but use Gelatin to make milk pudding for something solid(ish).  Pannacotta I suppose!

[Cari]

My friend told me that her friend credits conquering her breast cancer by eating cherimoya every day.

[J.R.K]

Kevin007 wrote:

Thank you J.R.K! I always need reminding to get more glycine in my diet. I might start a raw milk only diet but use Gelatin to make milk pudding for something solid(ish). Pannacotta I suppose!

 

I am a big fan of collagen for my daily protein needs . I posted this section of the article to give a possible conversion factor moving from a mouse model dosage to a human dosage per your question above.

[Cari]

@Zack-Vegas what is a good iron lab range in the Ray Peat world for a person to get down to or up to? I know the good range in modern medicine is too high.

[Zack-Vegas]

I think Ferritin is the best marker for total body iron stores.  The lab range for men is 30 to 400 ng/mL, and I think it’s 25 to 300ng/mL for women.

The Zacharski trials showed a lower mortality rate for men with ferritin levels at 80ng/mL or below.  So, a good target range would probably be about 25-80ng/mL.  I tend to favor the lower end of that range.  I’ve heard some people say that the lower end might be too low, and that a ferritin target of about 40-60ng/mL might be better, especially if you are highly active.  Although I have tested as low as 18 ng/mL, and felt great, and showed no anemia symptoms.  My hemoglobin number was above 13.5, and that seems to be the most important number in regards to anemia concerns.

So, 25 to 80 ng/mL is a good target.

[Cari]

Thank you @Zack-Vegas for your reply. I forwarded it to my friend.

[Kevin007]

So I’m home from City of Hope.  I really like their approach, the people, and their dedication to research.
I had a PET scan done on Tuesday and went over the results with the Oncologist this morning.
Apparently, the Niacinamide, Thiamine, Biotin & Aspirin protocol had negligible effect… the same spots that showed up in the MRI over the summer lit up on the PET.  Luckily, nothing showed up in the Lungs, but there was a small lesion that lit up in my liver.
The oncologist said I should focus on my liver first.  He suggested this new treatment called Histotripsy.  It uses high frequency ultrasound and does not damage any surrounding tissue.  Luckily, they have it at the University of Michigan (where I’ve had surgery and radiation before) and I believe I would qualify.
As far as treating the existing head and neck tumors – I have a few options.
1: Clinical trial at Memorial Sloan Kettering using AVA6000 – a novel new targeted chemo drug that is effective on head and neck cancers but has a much lower side effect profile.
2: Use my existing DNA information (from 6 years ago) along with the new genenetic test results from Sloan Kettering, to find new genetic markers/oncogenes that may be targeted in clinical trials
3. Continue with “alternative/functional” treatments.  I’ll probably try baking soda treatment – direct aspirin or acetic acid injections into tumors, Altitude tents, and others.

Thanks for staying with me on this journey… as always, your input and support is appreciated!

[Author]

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