[Kevin007]

Quick question…
My doctor has me taking DCA (sodium dichloroacetate) as part of my protocol. I’m supposed to take it with a fair amount of Thiamine.
I looked it up and Dr. Peat seems to possibly contradict himself regarding DCA. Or maybe amounts and duration are what he’s referring to:

Heart failure, shock, and other problems involving excess lactic acid can be treated “successfully” by poisoning glycolysis with dichloroacetic acid, reducing the production of lactic acid, increasing the oxidation of glucose, and increasing cellular ATP concentration. Thyroid, vitamin B1, biotin, etc., do the same.
– Ray Peat

“Unfortunately, the toxin that has become standard treatment for lactic acidosis–dichloroacetic acid–is a carcinogen, and eventually produces liver damage and acidosis. But several nontoxic therapies can do the same things: Palmitate (formed from sugar under the influence of thyroid hormone, and found in coconut oil), vitamin B1, biotin, lipoic acid, carbon dioxide, thyroid, naloxone, acetazolamide, for example.”– Ray Peat

Any thoughts on this?

[Kevin007]

I had a new comprehensive metabolic blood test a couple weeks ago.  This was my functional doctors request.  If I really want to know my true metabolic situation, I should get other ratio tests like NADH/NAD+, cortisol/DHEA, cortisol/androgens, cortisol/progesterone etc.
As you’ll see, I’m way over in C-reactive protein (inflammation right?) and a few others are over like ALK Phosphatase plus chloride & Glucose (slightly)
Vitamin A is very low too.

CHEMISTRY

COMP METABOLIC

SODIUM.                                       144                136-145

POTASSIUM                                 4.0                 3.4-5

CHLORIDE                                107                98-107

CARBON DIOXIDE                     31                   22-32

ANION GAP                                   10                   9-17

GLUCOSE                                 100                 74-99

BUN                                                18                    7-20

CREATININE                           0.7                   0.8-1.5

GFR (estimated)                           104

B/C Ratio                                   26                   10-20

Total Protein                                 7.2                    6.3-8.2

Albumin                                        4.2                     3.5-5

A/G Ratio                                      1.4

Calcium                                          9.2                    8.4-10.2

Bilirubin total                               0.6                    0.2-1.3

ALT (SGPT)                                   19                      <50

AST (SGOT)                                  28                     15-48

ALK Phosphatase                    162                  34-126

Ferritin                                            33.7                 18-464

Homocysteine                                8.9                   6.6-14.8

C-Reactive Protein                        10.37               1.0-3.0

SED Rate                                     18                     0-15

Estradiol                                          27.59                0-66

Progesterone                            1.04                  0.1-1.0

Thyroproxidase antibody            0.5                      <9.0

Copper                                             126                     73-129

Dehydroepiandrosterone             123                     20-299

G6PD Enzyme                                 9.1                     8.0-11.9

Insulin                                              13.1                    2.6-24.9

Magnesium                                      5.2                     4.0-6.4

Sex Hormone Binding Glob.        39.5                   11.3-89.5

T3, Reverse                                      15                       10-24

Testosterone, free                           13.6                   3.87-14.7

Testosterone Total                          592                    240-950

Thyroglobulin Antibody                <1..8                   <4.0

Vitamin A                                      30.1                   32.5-78.0

Zinc                                                     66                        60-106

[Kevin007]

I think because I have 3-4 active tumors right now,  it may be appropriate to treat myself three ways…
1. Cytotoxic Treatments – things like mistletoe, vitamin C IV’s, bee venom and maybe a “safe” clinical trial for a targeted chemo drug.
2. A metabolic correction approach – Haidut’s biotin, nicacinamide, thiamine & aspirin
3. Additional products to regulate cancer gene cells like rosemary extract, green tea extract, gingko biloba, berberine and more.

the spot on my liver requires a more immediate approach.  I don’t want to risk that spot getting out of control.

[Kevin007]

Yeah, I was wondering about the “sudden” appearance of a liver tumor.  However, the area hasn’t been scanned in a while, and the liver is a place it would likely metastasize.  I couldn’t help but think the hot spot couldn’t be from something else, maybe an overworked area processing all the supplements I’ve been taking :-/.
I am definitely leaning towards histotripsy, but after speaking with the specialists, the tumor is larger than they typically work on.  In theory, they could do two passes, but they don’t have any data on the success rate of multiple ablations, and I’d be under anesthesia for something like 6-7 hours.
The oncologist are recommending Y-90 radioembolization which is a minute amount of radiation at the tumor site.  Not ideal as far as the CT’s and digital moving x-rays they need, but it does have good results.

In the meantime, I have a natural/functional health provider that I’m working with.  She’s a DO that helped her husband and a colleagues brother overcome cancer.  She recommends a multi-pronged approach.  My hope is that it can provide immediate results, maybe even shrinking the tumor in my liver enough to use Histsotripsy instead of Y90.
The DO’s approach uses a few more commonly recognized “European” therapies.
A great deal of blood tests from a company called RGCC –   RGCC is a type of cancer blood test developed by a Swiss company. It aims to detect, analyze, and monitor cancer cells at various stages of the disease. The tests focus on identifying circulating tumor cells (CTCs) and their concentration in the blood, which can provide valuable insights into cancer presence and treatment effectiveness.  It should provide insight into the effectiveness of common chemotheraputics and natural extracts/chemicals like Bee Venom or Sulphurophane.
I’m waiting for those results to come back, but in the meantime she’s started a protocol.  Most of the products on the list I’m fine with – like Ivermectin, Fenbendozole, Mistletoe Extract, Rosemary Extract, Green Tea Extract, Low Dose Naltrexone, D3, K2, Liposomal Vit. C, & Ginko.  Some things I’m not sure about include Melatonin, Pancreatin (I think it’s just a digestive enzyme) and OmegaMax (which is an Omega 3 oil meant to target Cox2, h-TERT, Ras/Raf/MEK/Erk, IGFR 1&2 and EpCAM).  I believe several other natural products I’m already taking will target the same things (curcumin/green tea), and if it’s a flavanol that may be targeting those genes, I’ll just have some olive oil!

She also has IV’s of Vitamin C  Ozone.   I have not studied the Ozone but I’m assuming it’s relatively safe.

Another set of “potential” additions include the Care Oncology protocol of
Metformin, Atorvastatin and Doxycycline.  These are not hard recommendations, but I’ll tell her I’m fine with Doxy, but not the others.  I’m sure I can find plenty of (Peat) acceptable alternatives.  The Care Onclology protocol is all about “starving’ cancer – so it sees sugar, more than fat, as a target for extreme reduction.  I’ll continue to use something in Haidut’ss protocol like aspirin or niacinamide to correct the issues with lipids.

She recommends quite a few other things, like Hyperthermia/sauna, detox (coffee enemas) and a low carb/keto diet.  Naturally, I’m not a fan of the low carb diet, and increasing fat isn’t an option – I’m seriously considering a raw milk only diet.   She recommends 60-80 carbs a day – If I had a 1/2 gallon of milk a day, it would be 60g protein and 90ish grams of carbs.  I could attempt to filter it to get it down to 3-4 percent fat, which I think would be acceptable.

One of my concerns is liver health & safety.  I’m not sure I should over -stress it right now with an active tumor.  I’m trying to discern which supplements might be problematic and necessitate  a cautious approach.

[Kevin007]

So I’m home from City of Hope.  I really like their approach, the people, and their dedication to research.
I had a PET scan done on Tuesday and went over the results with the Oncologist this morning.
Apparently, the Niacinamide, Thiamine, Biotin & Aspirin protocol had negligible effect… the same spots that showed up in the MRI over the summer lit up on the PET.  Luckily, nothing showed up in the Lungs, but there was a small lesion that lit up in my liver.
The oncologist said I should focus on my liver first.  He suggested this new treatment called Histotripsy.  It uses high frequency ultrasound and does not damage any surrounding tissue.  Luckily, they have it at the University of Michigan (where I’ve had surgery and radiation before) and I believe I would qualify.
As far as treating the existing head and neck tumors – I have a few options.
1: Clinical trial at Memorial Sloan Kettering using AVA6000 – a novel new targeted chemo drug that is effective on head and neck cancers but has a much lower side effect profile.
2: Use my existing DNA information (from 6 years ago) along with the new genenetic test results from Sloan Kettering, to find new genetic markers/oncogenes that may be targeted in clinical trials
3. Continue with “alternative/functional” treatments.  I’ll probably try baking soda treatment – direct aspirin or acetic acid injections into tumors, Altitude tents, and others.

Thanks for staying with me on this journey… as always, your input and support is appreciated!

[Kevin007]

Thank you J.R.K!  I always need reminding to get more glycine in my diet.  I might start a raw milk only diet but use Gelatin to make milk pudding for something solid(ish).  Pannacotta I suppose!

[Kevin007]

So House of Hope did blood work yesterday and I’m scheduled for a PET scan in an hour.
some interesting blood results!  Low Iron and high TSH among the oddities.

Glucose Level (Random), Blood (CHI)
Normal range: 74 – 106 mg/dL
98 mg/dL

Blood Urea Nitrogen Level, Blood (CHI)
Normal range: 6 – 20 mg/dL
16mg/dL

Creatinine Level, Blood (CHI)
Normal range: 0.70 – 1.20 mg/dL
0.72 mg/dL

Calcium Level, Blood (CHI)
Normal range: 8.6 – 10 mg/dL
9.3 mg/dL

Bilirubin Total, Blood (CHI)
Normal range: 0.0 – 1.2 mg/dL
0.3 mg/dL

Protein Total, Blood (CHI)
Normal range: 6.4 – 8.3 g/dL
7g/dL

Albumin Level, Blood (CHI)
Normal range: 3.5 – 5.2 g/dL
3.6g/dL

SGOT (AST) (CHI)
Normal range: 0 – 40 U/L
19 U/L

SGPT (ALT) (CHI)
Normal range: 0 – 41 U/L
12 U/L

Alkaline Phosphatase Level, Blood (CHI)
Normal range: 40 – 130 U/L
179 U/L

Sodium Level, Blood (CHI)
Normal range: 136 – 145 mmol/L
141 mmol/L

Potassium Level, Blood (CHI)
Normal range: 3.5 – 5.1 mmol/L
4.9 mmol/L

Chloride Level, Blood (CHI)
Normal range: 98 – 107 mmol/L
103.9 mmol/L

Carbon Dioxide Level, Blood (CHI)
Normal range: 22 – 29 mmol/L
27 mmol/L

eGFR, Blood CHI
Normal range: above >=60 mL/min/1.73 m²
Value >=60

Anion Gap, Blood (CHI)
Normal range: 5 – 15 mmol/L
10 mmol/L

Albumin / Globulin Ratio (CHI)
Normal range: 1.0 – 2.0
1.1

BUN / Creatinine Ratio (CHI)
Normal range: 10 – 20 RATIO
22 *high*

Calcium Level Corrected, Blood (CHI)
Normal range: 8.6 – 10 mg/dL
9.62 mg/dL

Activated Partial Thromboplastin Time (CHI)
Normal range: 22.5 – 34.7 Seconds
27.9 seconds

Activated Partial Thromboplastin Time (CHI)
Normal range: 22.5 – 34.7 Seconds
27.9 seconds

Iron, Blood (CHI)
Normal range: 59 – 158 ug/dL
61 ug/dL

Total Iron Binding Capacity (CHI)
Normal range: 250 – 450 ug/dL
275 ug/dL

Iron Saturation Percent (CHI)
Normal range: 20.0 – 55.0 %
22.25

Unsaturated IBC (CHI)
Normal range: 112 – 347 ug/dL
214 ug/dL

Iron, Blood (CHI)
Normal range: 59 – 158 ug/dL
61 ug/dL

Total Iron Binding Capacity (CHI)
Normal range: 250 – 450 ug/dL
275 ug/dL

Iron Saturation Percent (CHI)
Normal range: 20.0 – 55.0 %
22.2 %

Unsaturated IBC (CHI)
Normal range: 112 – 347 ug/dL
214 ug/dL

Protime (CHI)
Normal range: 11.5 – 13.9 Seconds
13.5 seconds

Inr (CHI)
Normal range: below 3.00 Ratio
1.04
INR THERAPEUTIC RANGE 2.0-3.0

Vitamin D, 25-Hydroxy (Screening for insufficiency) (CHI)
Normal range: 30 – 100 ng/mL
74.98 ng/mL

WBC Count (CHI)
Normal range: 4.00 – 10.50 K/uL
4.82 K/uL

RBC (CHI)
Normal range: 4.70 – 6.00 M/uL
4.59 M/uL

Hemoglobin (CHI)
Normal range: 13.5 – 18.0 g/dL
13.4 g/dL

Hematocrit (CHI)
Normal range: 42.0 – 52.0 %
42.6%

MCV (CHI)
Normal range: 78 – 100 fL
93 fL

MCH (CHI)
Normal range: 27.0 – 32.0 pg
29.2 pg

MCHC (CHI)
Normal range: 32.2 – 36.5 g/dL
31.5 g/dL

Platelets (CHI)
Normal range: 150 – 450 K/uL
218 K/uL

RDW (CHI)
Normal range: 11.5 – 14.0 %
13.7%

MPV (CHI)
Normal range: 9.0 – 12.0 fL
9.1 fL

Neutrophils Percent (CHI)
Normal range: 58 – 66 %
73 %

Lymphocyte Percent (CHI)
Normal range: 21 – 33 %
16%

Monocyte Percent (CHI)
Normal range: 4 – 8 %
9%

Eosinophil Percent
Normal range: 2 – 4 %
2 %

Basophil Percent (CHI)
Normal range: 0 – 1 %
1 %

NRBC Percent
%
Value
0.0

Neutrophil Absolute
Normal range: 1.5 – 6.6 K/uL
3.51 K/uL

Lymphocyte Absolute
Normal range: 1.8 – 3.3 K/uL
0.79 K/uL

Monocyte Absolute
Normal range: 0.10 – 1.00 K/uL
0.41 K/uL

Eosinophil Absolute
Normal range: 0.00 – 0.70 K/uL
0.07 K/uL

Basophil Absolute
Normal range: 0.00 – 0.10 K/uL
0.03 K/uL

Immature Grans (CHI)
Normal range: 0.0 – 0.0 %
Value 0.2 %

Absolute Immature Granulocytes (CHI)
Normal range: 0.00 – 0.10 K/uL
0.01 K/uL

Thyroid Stimulating Hormone, Serum (CHI)
Normal range: 0.270 – 4.200 uIU/mL
5.08 uIU/mL

Vitamin B12 Level, Blood (CHI)
Normal range: 232 – 1,245 pg/mL
Value
>4,000

Ferritin Level, Blood (CHI)
Normal range: 30 – 400 ng/mL
46.25 ng/mL

Free T4 (CHI)
Normal range: 0.92 – 1.68 ng/dL
.96 ng/dL

Folate, Serum (CHI)
Normal range: 7.3 – 26.1 ng/mL
8.9 ng/mL

I input all this into AI and asked it to “diagnose” based on the data alone and this is what it said:

Based on this constellation of findings, I suspect subclinical hypothyroidism with concurrent iron deficiency anemia and possible chronic low-grade inflammation or stress response.

I’ve been taking quite a bit of thiamine, niacinamide, biotin and aspirin.  I’m wondering if that would affect liver function and Thyroid? Especially if I didn’t get enough nutrition(glucose) to support the potential increase in metabolism?

High B12 could be from the eggs I eat😁

Thoughts?

[Kevin007]

I’m going to the City of Hope Cancer Center tomorrow for a third opinion.   I believe it will be a 50:50 split of conventional and functional.

Also, thanks to <span class=”atwho-inserted” contenteditable=”false” data-atwho-at-query=”@haidut”>@haidut</span> , we have the Human Equivalent Dose (HED) data for aspirin, vitamins B1, B3, and B7 in cancer treatment studies conducted on mice. Given that mouse metabolism differs significantly from humans (presumably running much faster), I’m wondering if there’s a standard time conversion factor we should consider.

For instance, if we see positive results in mouse studies—like tumor size reduction—over a specific timeframe, I assume the timeline would translate differently in humans. Does anyone know what that conversion factor might look like, or if such a standardized conversion even exists?

[Kevin007]

Any thoughts on MB dosing?  It seems to vary widely.

[Kevin007]

I think my calculations for MB dosage may be incorrect – I created an HED calculator and came up with the following:

The HED for 50MG/KG per day of MB for a mouse would be as follows:
195lbs = 195/2.2 = 88.6kg
The BSA (body surface area) calculator  gives us a BSA of 2.12m2
This results in a human K*m* factor of 89/2.12 or 42
The K*m* factor for a mouse is 3
The mg/kg HED is (50 x 3) / 41.88 = 3.58
Therefore the complete HED is 3.46mg/kg x 88.6 = 317mg

So somewhere around 300mg over the course of a day.

[Author]

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