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A very interesting study on Niacinamide, and one that I am a bit surprised that Haidut never seemed to find. In this study, researchers tested out two doses of regular Niacinamide in addition to a high fat diet. Both doses seemed to protect against weight gain, and the High Dose seemed to keep the mice lean. Niacinamide also lowered inflammatory markers like TNF Alpha, and IL-6, lowered Free Fatty Acids, raised NAD+ and the NAD+/NADH ratio, and increased Adiponectin. Niacinamide also seemed to suppress both SCD1 and Fatty Acid Synthase, both of which are overexpressed in Obesity.
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100111
On the old RPF, there was talk that Niacinamide may actually prevent fat loss, but this study showed the opposite. In fact, it suggested that FAO actually increased on both Niacinamide doses.
It seems like when losing fat/weight, there is a “metabolic block.” Pretty much everyone who has tried to diet has experienced this at some point, from either battling hunger, having low energy, or hitting the dreaded plateau. Based on some of Brad Marshall’s videos, I suspect the “metabolic block” is from relying on excess FAO, which causes a buildup of NADH, as opposed to relying mainly on carbs, which seem to generate plenty of NAD+. This study seems to suggest that Niacinamide will create extra NAD+ to increase metabolism, even if the organism is relying more on fat for energy instead of carbs. When losing weight/fat, there probably is going to be a fair amount of FAO, even if you are eating a high carb/low fat diet.
The doses used in the study were pretty high. The “Low Dose” would be about 1.8 grams of Niacinamide for a 70kg person, and the high dose closer to 8 grams. I think there were some studies suggesting issues with Niacinamide over 4 grams per day, specifically liver issues. A better solution might be to use Niacinamide closer to the “Low Dose” in the study, and some sort of redox agent that has been shown to convert NADH back to NAD+, like Methylene Blue or Alpha Lipoic Acid, in addition to a higher carb and lower fat diet.
Interesting study, I would consider niacinamide to be a much safer option than the GLP-1 agonists. I wonder though if a high dose even at 1.8 grams would be better if dissolved in water and sipped on throughout the day as opposed to one or two large doses at a time. This might be more in line with Dr Peat’s line of thought on niacinamide.
Any thoughts on adding some thiamine with this protocol?
Well, the GLP 1 agonists are new drugs, and carry a host of very negative potential side effects, even from what we’ve already seen, like stomach paralysis. I think crash dieting, extreme fasting, exhaustive exercise, low carb/keto diets, and extreme vegan diets are all safer, even though they all carry a lot of potential issues as well. Even risky medications like Orlistat, HCG, and phentermine are likely safer. Pretty much the only intervention that seems riskier to me is gastric bypass. So, while incredibly popular right now, I don’t think the GLP 1 agonists are very good benchmarks for safety.
Niacinamide, even in higher doses, is very safe. We have a long history of people using higher doses of Niacinamide and Niacin, thanks to Abram Hoffer and the orthomolecular doctors. I’m not sure exactly what line of thinking of Dr. Peat’s you are referring to. He did generally recommend a hundred milligrams a few times a day, but again, that was mostly general advice. He talked about experimentation with safe substances, like aspirin, and noted that a person could experiment with just aspirin in various doses, from a baby aspirin up to several grams a day. I don’t see why Niacinamide would be any different, and if anything, it would be safer than aspirin. Even taking a larger dose at once, it tends to be absorbed from the gut over time, so I don’t think the slow sipping of niacinamide in dissolved water would be necessary. It seems like it would be more of a complication, causing issues with compliance. Plus, niacinamide powder tastes very bitter, so that would be another issue.
Adding thiamine would be a very good thing, and there are studies also showing higher doses of thiamine helping to prevent weight gain on a high fat diet as well. In Haidut’s classic post on the NAD+/NADH ratio, he mentions that a combo of Niacinamide, Thiamine, Biotin and maybe Methylene Blue would be a very useful combo for practically all conditions, as they all help to stimulate metabolism.
https://lowtoxinforum.com/threads/nad-nadh-ratio-the-one-metabolic-cause-to-rule-them-all.20089/
MB can cause some potential issues of its own, likely to the MAO-A inhibition and interactions with red light. There are other things that can help oxidize NADH back to NAD+, like Alpha Lipoic Acid, Inosine, Pyruvate, CoQ10, and Pyrucet. Red Light itself may oxidize NADH back to NAD+, since it seems to lower lactate, and the pyruvate/lactate ratio is a good surrogate for the NAD+/NADH ratio.
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