Cancer again – Is this the End, or just the beginning?

[Zack-Vegas]

<span class=”atwho-inserted” contenteditable=”false” data-atwho-at-query=”@j”>@J.R.L</span> From everything I have read by Iron Researchers and Specialists, Ferritin, as measured by blood test, is the best marker for full body iron stores.  I never heard of any of them using a hair or nail test, maybe they are too new for that.  Ferritin is relatively stable when compared to other markers, Serum Iron reacts to food intake (similar to blood glucose), so it can spike from a meal, especially one higher in iron (like if you ate a steak).  TSAT is a calculation based on Serum Iron and Iron Binding Capacity, so also has the potential to move dramatically, based on a meal.

Ferritin is also the primary marker used when a patient is getting deironed.  It falls with blood donation (aka phlebotomy) pretty reliably.  I saw this myself when I decided to get deironed.  It’s a process that can take months, so it is a longer term trend.  Although the rule of thumb is that Ferritin will lower about 30 ng/dl with each blood donation.  It’s a very rough calculation, as very high ferritin levels can drop quicker in the beginning, and it doesn’t drop nearly as dramatically as you approach the lower end of the scale.

[Lilac]

I found more Ray interviews on The Herb Doctors’ own website:

https://www.westernbotanicalmedicine.com/pages/ask-your-herb-doctor

 

[Kevin007]

Question about fats:

I’ve been going very low fat for a couple weeks now – and relatively low protein (30-50 grams) but I’ve been unsure about fats. I feel like I should be getting some coconut oil (for the anti-inflammatories), or my low pufa eggs (for the cholesterol).
What is your understanding of fats and their effect on (cancer) metabolism? Is all fat problematic or are saturated fats ok? (Btw, I’ve been taking aspirin and meldonium to bypass FAO/FAS

[Zack-Vegas]

From Ray Peat’s article on Caner: Disorder and Energy-

“The alkaline cancer cell surrounds itself by the acid that it emits, and this extracellular
acidity increases the ability of fatty acids to enter the cell (Spector, 1969); cancer cells,
although they are synthesizing fat, also avidly take it up from their environment
(Sueyoshi and Nagao, 1962b). This fat avidity is so extreme that cancer cells in vitro will
eat enough polyunsaturated fat to kill themselves. This has been offered as proof that
fish oil kills cancer. Saturated fats, however, have a calming effect on cancer cells,
inhibiting their aerobic glycolysis (Marchut, et al., 1986) while permitting them to resume
the respiratory production of energy.”

I think coconut oil is particularly good for supporting energy metabolism.  Not just due to the high saturation level, but also the shorter chain length.  Eating coconut oil should also have a beneficial effect on the gut, since it’s antibacterial, which should, over time, lower endotoxin and serotonin production.   Some fat is also good in the diet, to help with digestion and gallbladder function.  20-30 grams could be very useful for this.  It doesn’t have to be every day (I did a very low fat diet for a couple months, where most days I was under 10 grams, but did go up to 20-30 at least once a week, for this purpose).

[Kevin007]

A lot has happened since my last post.  I talked to my oncologist at UofM and they were “pushing” me into a particular clinical trial.  They told me that after analyzing my old biopsy sample, they found the cancer cells expressed an HER2 Low, androgen negative oncogene.  Armed with this information, they sought to put me on a breast cancer chemo drug; trastuzumab deruxtecan.   Even though it’s described as a “smart bomb and not a carpet bomb, there’s still quite a few side effects.  Additionally, while participating in the clinical trial, I could not do any of the “alternative or functional” treatments I’m doing now, or have planned.
They said it “could” extend my live up to 36 months or so – and reiterated that it “was not a cure”.  I can only imagine the treatment being worse than the disease. It didn’t sound like anything I wanted to try.
I went to Sloan Kettering in NY for a second opinion.   The oncologist there was straightforward and up front.  They have a clinical trial there as well, a new drug called AVA6000, a tumor targeted form of doxorubicin that has been chemically modified to reduce side effects by targeting the release of the active chemotherapy to tumour tissue.
The oncologist at MSK also said I could continue with Active Surveillance.  So I’m pursuing alternative treatments while actively surveilling my status.

I’ve been taking all the metabolic “enhancers” that are familiar to the Peat world… 4g Aspirin, Biotin, Niacinamide, Thiamine, QOQ10 (similar to the Georgi study, as well as Vitamin K, Curcumin, Meldonium, VitD, and Doxycycline.
I’m juicing every day with Tumeric, Garlic, Onion, Kale, green apple, lemon, oranges, carrots and broccoli sprouts.

I’m also looking at a clinic in Mexico called Sanoviv.  It’s a three week treatment with several interesting therapies like Hyperthermia, Vitamin B17, Vitamin C, Mistletoe, hydrotherapy/colonics, massage/meditation, and hyperbaric O2 and others.

Now I like some of those treatment ideas at Sanoviv, but it has some glaring issues – 1. Expensive, 2. In Baja Mexico, 3. Low Dose Cisplatin during Hyperthermia, 4. Chelation with EDTA
As an option, I may recreate this at home, some where I can control more of the treatment.  I found a clinic here in Michigan that does a test called RGCC+, that tests for:
-Circulating tumor cell (CTC) count
-Genetic and physiological expressions of your cancer cells
-Effectiveness of 90+ chemotherapeutic agents and targeted therapies on your cancer cells
-Effectiveness of 50+ natural substances on your cancer cells

This will let know which natural food substances are effective against my cancer (Allicins, Sulpurophane, etc).   They also do blood tests at the beginning for a baseline, mistletoe/Iscador, Hyperbaric, HOCATT , Ozone treatment, Chelation, and more.
If I go this route, I may purchase a sauna with red light, altitude tent, grounding pads, linen sheets etc.

I do have one question… I started taking some Methylene Blue, but I stopped until I could find out more about the dosage.

I found this 2024 trial for Ovarian Cancer, done In Vitro on Mice

2024 Ovarian Cancer Metabolic Therapy
Study: da Veiga Moreira et al. – Carboplatin-Resistant Model

🔸 In Vivo Dosage:

50 mg/kg/day continuously via drinking water
🔸 In Vitro Dosage:

50 μM in cell culture (selected for 50% viability response)
🔸 Delivery Methods:

In Vivo: Oral administration through drinking water
In Vitro: Direct addition to culture medium
🔸 Timing Protocol:

Treatment initiation: When tumors reached 200 mm³
Duration: 22 days continuous treatment
In vitro assessment: 4 hours (mitochondrial assays) or 24 hours (proliferation assays)

🔸 Key Result:

Significant tumor growth inhibition vs. carboplatin chemotherapy

THAT’S A LOT OF  METHYLENE BLUE!
Human dose would be:

For an 88 kg Human
4.07 mg/kg × 88 kg = 358 mg/day

Can anyone help confirm this, or supply an alternate dosing strategy?

 

[Kevin007]

I think my calculations for MB dosage may be incorrect – I created an HED calculator and came up with the following:

The HED for 50MG/KG per day of MB for a mouse would be as follows:
195lbs = 195/2.2 = 88.6kg
The BSA (body surface area) calculator  gives us a BSA of 2.12m2
This results in a human K*m* factor of 89/2.12 or 42
The K*m* factor for a mouse is 3
The mg/kg HED is (50 x 3) / 41.88 = 3.58
Therefore the complete HED is 3.46mg/kg x 88.6 = 317mg

So somewhere around 300mg over the course of a day.

[Kevin007]

Any thoughts on MB dosing?  It seems to vary widely.

[J.R.K]

<span class=”atwho-inserted” contenteditable=”false” data-atwho-at-query=”@Kevi”>@Kevin007</span> Dr Mercola has an article on Methylene Blue and cancer treatment. Here is an excerpt from that article.
He recommended that Methylene Blue be combined with photo dynamic therapy. A dosage of five Mg was his recommendation. But with all the other things that you are doing it is probably good to keep that line of communication open with your doctors to ensure there are no contraindications.

Q: How is methylene blue taken for cancer therapy?

A: The most effective and safest method is pharmaceutical-grade methylene blue in capsule or tablet form, with a standard dosage of 5 mg once daily for mitochondrial support.
Q: Can methylene blue be combined with other cancer treatments?

A: Yes, research shows that methylene blue enhances the effects of chemotherapy drugs like carboplatin. It also strengthens the immune system’s response to tumors, which will help improve long-term outcomes. More studies are needed to determine the best combinations and dosing strategies for different cancer types.

The article is pretty informative it might be worth a read.

 

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