One compound of note that I have stumbled across once again that I had not considered in awhile is that of the compound known as Urolothin A. It appears to be gaining ground in research for its role in mytophagy and clearing of damaged or dead mitochondria from the cell. It plays a role in obesity, glucose resistance, inflammation as well as energy production. The role it plays in brain health in terms of reducing or possibly preventing dementia in tau plaque build up draws a parallel to diabetes mellitus as these are as some tend to believe are related ie Type two and in terms of the brain type three diabetes.
What I found interesting in this report was that Urolithin A is produced in the microbiome and that only about forty percent of the population produce this substance (which population was researched was not revealed). But for those that struggle with metabolic issues this might be something to look at in terms of an experiment to supplement with as there are foods that do contain the polyphenols required for the production of Urolithin A such as pomegranates, strawberries and walnuts, but if you do not have the proper blend of bacterium in your microbiome you may not be able to produce Urolithin A. But you can supplement with it. This video on the topic gives a decent overview but there is still much to be learned on this and as with many things in a biological entity it is never a matter of just one compound but how that increase in one element interacts with every other element and their current levels inside the organism that are factors in the results for energy production.
Author
J.R.K